Artefill is the first and only FDA-approved non-resorbable wrinkle filler used for the correction of smile lines. Artefill contains PMMA microspheres and purified Bovine collagen gel with an anesthetic for comfort during injection. Artefill is a dual-acting wrinkle filler that provides immediate and long lasting results. First, collagen visibly corrects the wrinkle. The microspheres then provide for the development of collagen stimulation to create the permanent support your skin needs for enduring wrinkle correction. Before your initial treatment with Artefill, a skin test is required. Dr. Werschler is an FDA clinical trials investigator for Artefill.